Mango Supplementation: A Promising Approach to Combat Obesity-related Inflammation


Excess weight and obesity have become prevalent public health concerns worldwide, posing significant challenges for individuals and healthcare systems alike. According to the World Health Organization, global obesity rates have doubled since 1980, leading to increased risks of chronic diseases such as diabetes and cardiovascular disease. To tackle this issue and its associated comorbidities, effective strategies are needed to prevent and address obesity and its consequences. One intriguing approach involves incorporating specific fruits, like mangoes, into the diet due to their potential to combat obesity-related disorders and inflammation.

Exploring the Link Between Obesity, Inflammation, and Chronic Disease

Obesity triggers a cascade of physiological and metabolic processes that promote a pro-inflammatory state, contributing to the development of various chronic diseases. Under normal conditions, the body secretes anti-inflammatory cytokines, such as adiponectin, to maintain homeostasis and reduce inflammation. However, in the case of obesity, pro-inflammatory adipocytokines increase while anti-inflammatory cytokines decrease, resulting in a chronic low-grade inflammatory state. Key mediators involved in this relationship include leptin, adiponectin, interleukins (IL-1b, IL-6, IL-17A), tumor necrosis factor α (TNF-α), monocyte chemoattractant protein-1 (MCP-1), superoxide dismutase (SOD), and C-reactive protein (CRP).

The Role of Diet in Reducing Obesity-related Inflammation

Intervention strategies aimed at reducing inflammation and excessive adiposity to prevent obesity-related chronic diseases commonly involve increased physical activity and a healthy diet. Consumption of refined carbohydrates, high-fat diets, and added sugars negatively impact blood glucose, insulin, and inflammation. In contrast, incorporating fruits with natural carbohydrates, such as mangoes, has shown potential for positively affecting inflammation and obesity. Studies have demonstrated that mango supplementation can reduce adiposity, lower blood glucose concentrations, and decrease serum CRP levels in obese individuals.

Unlocking the Power of Mango Supplementation

Mangoes are not only a delicious fruit but also a rich source of dietary fiber, polyphenols (including mangiferin), carotenoids, and ascorbic acid. These bioactive compounds and antioxidant nutrients have exhibited anti-inflammatory and antidiabetic properties in both human and animal models. Recent studies on mango powder supplementation have shown promising results, including lower blood glucose levels in obese individuals. Given that elevated blood glucose is associated with inflammation, the reduction in blood glucose observed with mango supplementation suggests a potential for reducing inflammation as well.

Investigating the Effects of Mango Supplementation

Building upon previous findings, this study examined the effects of consuming freeze-dried mango daily for 12 weeks on anthropometric measurements, serum lipids, and inflammatory markers among obese individuals. The hypothesis is that the inclusion of mango in the diet will not only lower blood glucose but also have positive effects on body composition, lipid profile, and inflammatory response in obese individuals.

At BDK Restaurant, we recognize the importance of finding innovative strategies to address obesity-related inflammation and its impact on overall health. As we await the results of this study, consider incorporating mangoes – a natural and potentially beneficial fruit – into your diet. To learn more about BDK Restaurant and discover a wide range of delectable dishes, visit BDK Restaurant.

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